ABSTRACT: This study aimed to investigate and compare the clinical roles of three important cytokines Tumor necrosis factor - α (TNF-α), Interferon-ƴ (IFN-ƴ) and Interleukine-6 (IL-6 ) in the pathogenesis of EHV-9, EHV-1 and Zebra borne EHV-1. Eighty four male Syrian hamsters were used in this study, divided into four groups, each group included twenty one animals, The 1st group served as the control group and received 50 μl of MEM–α medium by intranasal administration. The 2nd , 3rd, and 4th group received 50 μl of a solution containing 1 × 104 PFU of EHV-9, EHV-1, and Zebra borne EHV-1 respectively by intranasal route. Hamsters were observed for clinical signs and body weight gain three times daily..........
Keywords: Cytokines, EHV-1, EHV-9, Zebra borne EHV-1, Pathogesis.
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