Abstract: Since its outbreak in December-2019, in Wuhan-China, the corona virus disease (COVID-19) caused by severe acute respiratory syndrome corona virus-2 (SARS- CoV-2) has become a global threat to human health with confirmed cases exceeding 24 Million and nearly 8,22,000 deaths reported worldwide as of August 27, 2020. During previous SARS epidemic, as per studies around 60% patients suffered with various degrees of liver damage. Most of the studies on COVID-19 focused on the lung injury of COVID-19, however recent studies are unfolding the fact that liver injury is also a major effect of COVID-19 in patients. This review summarizes the available data on liver abnormalities related to COVID-19 and critically evaluates the possible causes of livery injury and provide recommendations and references for clinical treatment and management.
Key Words: COVID-19, SARS-CoV2, Liver Injury, Cholangiocytes, Ace-2.
[1]. de Groot, R. J., Baker, S. C., Baric, R., Enjuanes, L., Gorbalenya, A. E., Holmes, K. V., ... & Woo, P. C. Y. (2012). Family coronaviridae. Virus taxonomy, 806-28. [2]. Chau, T. N., Lee, K. C., Yao, H., Tsang, T. Y., Chow, T. C., Yeung, Y. C., ... & Lai, C. L. (2004). SARS‐associated viral hepatitis caused by a novel coronavirus: report of three cases. Hepatology, 39(2), 302-310. [3]. Chai, X., Hu, L., Zhang, Y., Han, W., Lu, Z., Ke, A., ... & Cai, J. (2020). Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection. biorxiv. [4]. Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., ... & Yu, T. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet, 395(10223), 507-513. [5]. Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., ... & Cheng, Z. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet, 395(10223), 497-506.