Abstract: Background: The yeasts are commensal in healthy humans and may cause systemic infection in immuno-compromised patients, due to their great adaptability to different host niches. The genus composed of a heterogeneous group of organisms, and approximately 17 different Candida species are found to be aetiological agents in human; however, more than 90% of invasive infections are caused by Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis and Candida krusei. Its progression results in invasive infections, which are a significant cause of morbidity & mortality. Also, increasing resistant to antifungal drugs has paved the path for in vitro laboratory tests of active plant ingredients that may aid the clinician in choosing an appropriate therapy........
Keywords: Candida albicans, C. Glabrata, Datura metel, AST, CHROM Agar & HPLC
[1]. Espinel-Ingroff, A., E. Canton, D. Gibbs, and A. Wang. Correlation of Neo-Sensitabs tablet diffusion results on three different agar media with CLSI broth microdilution M27-A2 and disk diffusion M44-A results for testing susceptibilities of Candida spp. and Cryptococcus neoformans to amphotericin B, caspofungin, fluconazole, and voriconazole. J. Clin. Microbiol.(2007); 45858-864.
[2]. Philippe Eggimann, JorgeGarbino et al. Epidemiology of Candida species infections in critically ill non-immunosuppressed patients. November 2003; 3(11): Pages 685-702.
[3]. S., Brindha S., Kaviyarasi N.S., Annadurai, B., and Gangwar, S.K.. Antimicrobial Activity of Leaf Extract of Neem (Azadirachta Indica Linn.). International journal of Science and Nature, 2012; 3(1): 110-113.
[4]. Johnson E., A. Espinel-Ingroff. Activity of voriconazole, itraconazole, fluconazole and amphotericin B against 1763 yeasts from 472 patients in the voriconazole phase III clinical studies. International J. Antimicrob. Agents, 2008; 32: 511–514.
[5]. Dongari-Bagtzoglou, A., Dwivedi, P., Ioannidou, E., Shaqman, M., Hull, D. & Burleson, J. Oral Candida infection and colonization in solid organ transplant recipients. Oral Microbiol Immunol , 2009; 24: 249–254.