Abstract: Background: The eighth most frequent gynecologic cancer in the world is ovarian cancer. Due to its advanced state at diagnosis, it is the worst gynecological cancer. Despite being a disease found in wealthy nations, its prevalence has been rising daily in underdeveloped nations like Bangladesh. While the majority of ovarian cancer cases are rare, women with BRCA 1 and BRCA 2 mutations, which indicate the hereditary basis of ovarian cancer, have an increased chance of developing epithelial ovarian cancer.
Objective: The aim of this study is to assess the outcomes in women with BRCA mutation & platinum-sensitive recurrent high-grade serous ovarian cancer.....
Keywords: Gynecologic malignancy, Ovarian cancer, High-grade serous carcinoma, BRCA 1 & 2 germline mutation, Clinical outcome, Survival outcome
[1]. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J. Clin. 68(6), 394–424 (2018).
[2]. Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A. and Bray, F., 2021. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 71(3), pp.209-249.
[3]. Hyman, D.M., Long, K.C., Tanner, E.J., Grisham, R.N., Arnold, A.G., Bhatia, J., Phillips, M.F., Spriggs, D.R., Soslow, R.A., Kauff, N.D. and Levine, D.A., 2012. Outcomes of primary surgical cytoreduction in patients with BRCA-associated high-grade serous ovarian carcinoma. Gynecologic oncology, 126(2), pp.224-228.
[4]. Jelovac, D. and Armstrong, D.K., 2011. Recent progress in the diagnosis and treatment of ovarian cancer. CA: a cancer journal for clinicians, 61(3), pp.183-203.Ahmad NZ, Byrnes G, Naqvi SA. A metaanalysis of ambulatory versus inpatient laparoscopic cholecystectomy. Surg Endosc 2008;22:1928–1934.
[5]. Labidi-Galy, S.I., Papp, E., Hallberg, D., Niknafs, N., Adleff, V., Noe, M., Bhattacharya, R., Novak, M., Jones, S., Phallen, J. and Hruban, C.A., 2017. High grade serous ovarian carcinomas originate in the fallopian tube. Nature communications, 8(1), p.1093