Abstract : In this paper a coupled cervical cancer model incorporating diffusion and diagnosis was formulated. Two transmission subsystems werecoupled in which the transmission rate at the population was expressedas a function of the viral load, while the within-host infection rates weremodelled as functions of the number of infectives. The basic reproduction number,𝑅0𝐶of the coupled model was found to be a maximum ofthe two reproduction numbers ......
Key Word: Coupledmodel,Diagnosis,HumanpapillomaVirus,Reproduction Number, Stability Analysis
[1]. AttiaS.,EggerM.,Mu¨llerM.,ZwahlenM.,LowN.2009.Sex- ual transmission of HIV according to viral load and antiretroviral ther-apy:systematic review and metaanalysis. AIDS 23(11):1397-1404 DOI10.1097/QAD.0b013e32832b7dca.
[2]. CarrJack(1981), Applications of Centre Manifold Theory, AppliedMathematicalSciences,Vol.35,Springer-Verlag,NewYork.
[3]. CliffordG.M.,Smith,J.S.,Plummer,M.,Munoz,N.,andFranceschi,S.(2003).Humanpapillomavirustypesininvasivecervicalcancerworldwide:ameta-analysis.Britishjournalofcancer,88(1),63-73.
[4]. Diekmann, O., Heesterbeek, J., Metz J.A. (1990). On the definition and the computation of the basic reproduction ratio in models forinfectious diseases in heterogenious populations. Journal of MathematicalBiology.167,67-78.
[5]. FengZ.,Velasco-HernandezJ.,Tapia-SantosB.and LeiteA.C.