Abstract: Acanthus montanus T. Anderson (Acanthaceae) possesses several medicinal properties; it is used in Cameroon as a folk medicine to treat pain, inflammation and threatened abortion. The aim of this study was to determine the effect of A. montanus aqueous extract on spermatogenesis in Swiss male albino mice and its mechanism of action.The extract, irrespective of dose, reversibly improved spermatogenic activity with 500mg/kg-1b.wt giving the most promising result. No significant reduction in body weight and weight of reproductive organs was observed and the gonadosomatic index remained stable irrespective of the increase in concentration of extract of A.momtanus. Increase in the spermatogenic indexes and total spermatogenic yield points to the potential of Acanthus montanus as a herbal –based remedy for spermatogenic dysfunction.
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